![]() ![]() Idarucizumab binds dabigatran with an affinity 350 times stronger than dabigatran binds thrombin. It irreversibly binds to dabigatran and has a rapid onset and slow offset. It specifically binds protein bound and unbound dabigatran and its active metabolites to form complexes, thus stopping dabigatran’s anticoagulant effects. Idarucizumab is a monoclonal antibody fragment that acts as a reversal agent to the direct thrombin inhibitor dabigatran.
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